Clear Sky Science – Articles (en)

TUMOR MICROENVIRONMENT ARTICLES

Efficacy and immunomodulatory effect of Claudin18.2-specific IL-7/XCL1 armored CAR-T cells in digestive tract cancer: preclinical and clinical analysis

Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression

AND logic nanoparticle for precision immunotherapy of metastatic cancers

Electrochemically optimized multi-component polyacrylonitrile nanofiber scaffolds as a platform for three-dimensional glioblastoma cell culture

Spatial profiling uncovers multicellular dynamics in early relapse of hepatitis B virus-associated follicular lymphoma

Pulmonary surfactant protein D reduces lung cancer progression associated with decreased IL-4/STAT6 signaling

Targeting erythroid progenitor cell metabolism to enhance cancer immunotherapy

A CAM bioimaging model reveals the connection between VEGFA vascular remodeling and enhanced sarcoma progression via tumor secretome

Key hub genes identification and therapeutic target prediction via multi-validation for the senescence-inflammation axis in prostate cancer

Graph neural network modeling of spatial tumor-immune interactions identifies prognostic cellular niches in non‑small cell lung cancer

AI-enabled single-cell dissection of the palmitoylation landscape identifies a multicellular prognostic program in gastric cancer

Combining AI to reveal CCDC3-mediated pathways of colorectal cancer liver metastasis

Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability

Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy

Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1–PD-L1 axis: a multi-omics and clinical validation study

Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics

Absolute dynamic and relative static: the relationship of glycolysis and OXPHOS in cancer development

NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis

Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton

Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas

Cancer-associated fibroblasts drive metabolic heterogeneity in colorectal cancer cells: predictions from metabolic modeling

RASIP1-positive TECs in pancreatic adenocarcinoma: a potential novel type of endothelial cells correlated with “hot” tumors

VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity

Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity

A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas

Multi-omics analysis of NEDD1 in hepatocellular carcinoma: biological function, prognostic value, and clinical significance

The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization

Comprehensive machine learning identifies anoikis signatures predicting therapeutic resistance and survival in gastric cancer

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

Encoding functional edges in graphs to model spatially varying relationships in the tumor microenvironment

HRCHY-CytoCommunity identifies hierarchical tissue organization in cell-type spatial maps

Immunophenotypic skewing of B cells toward IgD⁻CD27⁻IgG⁺ subtype and metabolic attenuation in colorectal cancer

Reconstructing single-cell resolution from spatial transcriptomics with CellRefiner

Pan-cancer analysis reveals the oncogenic and immunomodulatory roles of PTGFRN across human cancers

The Caspase-1-EGR4 axis regulates macrophage repolarization in acute myeloid leukemia cells

The research advances of crosstalk between cancer-associated fibroblasts and tumor cells using co-culture organoids

Navigating the complexities of ferroptosis in pancreatic ductal adenocarcinoma: roles, mechanisms and potential applications

Visualizing malignant progression: in situ CD109-based spatial immunofluorescence assay delineates papillary to anaplastic thyroid carcinoma transformation within the tumor microenvironment

SexTumorDB: a comprehensive resource of sex-dependent tumor landscape at single-cell resolution

Integrative machine learning and molecular docking reveal Narirutin targets ABCC1/ABCG2 for immune microenvironment remodeling in colorectal cancer

INHBA: a mitochondrial-related pan-cell death gene associated with the prognosis and immunity of OSCC

Fractal analysis of hepatocellular carcinoma vasculature shows regional differences independent of vascular invasion

DUSP29 does not regulate melanoma–myoblast interactions in a skeletal muscle co-culture model

Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models

Convergent genomic and molecular features predict risk of metachronous metastasis in clear cell renal cell carcinoma

Semaphorin 6D drives anti-tumor type I interferon responses to reprogram the tumor microenvironment in colorectal cancer

CAF-enriched COL4A6 promotes gastric cancer progression and stromal remodeling despite an inverse association in bulk transcriptomes

Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer

ITGA8 suppresses proliferation and metastasis of lung adenocarcinoma through the inhibition of glycolysis

COL3A1high cancer-associated fibroblasts orchestrate metabolic and immune microenvironments to confer chemoresistance in breast cancer

Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancer

VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement

Quinoline carboxylic acid derivatives as potent ectonucleotidase inhibitors

Association of retinoids, retinoic acid receptors and epigenetics in breast cancer

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical niches

Repression of miR-29 via MYC leads to increased CD40 signaling in transformed follicular lymphoma

CCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness

Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose–mesenchymal transformation

M2 macrophage–derived extracellular vesicles induce EMT-like transcriptional reprogramming in colorectal cancer cells via upregulation of FAM83A

Analysis of the mechanism and prognostic value of PRKCQ-AS1 in inhibiting the progression of lung adenocarcinoma via regulating the PD-1/PD-L1 pathway

Identification of core cytotoxic T lymphocyte-related subtypes, establishment of a prognostic model, and analysis tumor microenvironment infiltration in HNSC

MOV10, a novel immunotherapy and prognostic biomarker, contributes to glioma development by regulating autophagy

Charting cell-type-specific positive genetic interaction at single-cell resolution for lung adenocarcinoma

RBP4 interferes with tongue squamous cell carcinoma progression by inhibiting the PI3K/AKT signaling pathway and promoting macrophage M1-type polarization

LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial

Transcriptional activation of LINGO1 facilitates proliferation and immune escape in colorectal cancer

Chronic inflammation promotes gastric cancer progression via ADAM10-mediated cleavage of CX3CL1

The MEOX1-PAX1 axis coordinately regulates tumor cell malignancy and Treg differentiation in glioblastoma

Amelioration of colorectal cancer-associated fibroblasts in immunosuppressive microenvironment by ferroptosis-based nanotherapy

Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment

Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathway

Developing virtual physiology of human tumor tissue for malignancy assessment

Y chromosome-linked EIF1AY deletion drives sex differences in multiple myeloma

Metabolic crosstalk among cancer-associated fibroblasts, adipocytes and immune cells as an immunosuppressive tumor microenvironment driver

DCTPP1 drives immunosuppression and poor prognosis in breast cancer by promoting M2 macrophage polarization

Synthetic lethality of MCL-1 inhibition and CAR-T therapy in aggressive B-cell lymphoma

STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways

Large-Scale Histological Image Dataset with Metadata for Colorectal Cancer Microenvironment

Integrated bioinformatics and experimental validation identify CCDC78 as a prognostic biomarker in colon adenocarcinoma

Bacterial colonization of tumors drives immune activation and checkpoint blockade efficacy

Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis

Lipid metabolism classification of gliomas

Validation of chemoresistance phenotypes in pleural mesothelioma across 2D, 3D, and in vivo models

Role of atomic force microscopy in characterization of heterotypic cancer spheroids and their interaction with microplastic particles

Innate lymphoid cell heterogeneity and etiology-specific reprogramming in hepatocellular carcinoma

PLOD2 promotes proliferation, migration and invasion of colorectal cancer cells via PI3K-AKT-GSK3β signaling pathway

Valproic acid reverses macrophage-mediated temozolomide resistance in macrophage-rich gliomas

Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer

STING synergizes with TOX suppressing HO-1 expression to trigger ferroptosis in tumor-infiltrating CD8+ T cell and immunotherapy resistance

Integrative single-cell and machine learning framework reveals prognostic fibroblast subtypes and constructs a fibroblast-related risk signature in lung adenocarcinoma

DANST enables cell-type deconvolution in spatial transcriptomics using deep domain adversarial neural networks

Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell’s anti-proliferative effect on cancer cells

Hepatocytes functionally reprogrammed by KIAA1199-high colorectal cancer cells favour the accumulation of pro-metastatic Egr1+ neutrophils

Analysis of the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins using snFLARE-seq and mxFRIZNGRND

SHH pathway inhibition and astrocyte co-culture induce distinct responses in glioblastoma and cancer stem cells

Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer

H19 enhances pancreatic cancer proliferation and invasion by reducing miR-29c-5p’s inhibitory effects on ATF2/ECM1

PTGDS is a potential marker for lung adenocarcinoma identified in a pancancer analysis

Adipocyte-driven STAT3-ANGPT2-PTGIS axis promotes cutaneous metastasis in breast cancer and represents a targetable pathway

Pembrolizumab and epigenetic modification with azacitidine reshapes the tumor microenvironment of platinum-resistant epithelial ovarian cancer: a phase 2 non-randomized clinical trial

STAR (stroma-tumor AI risk) assessment: association of AI-derived tumor-stroma proportion with patient survival provides added prognostic value beyond KELIM in epithelial ovarian cancer

Proteomic atlas of human peritoneal tissue

Integrative analyses of metastatic cancer transcriptome reveal clinically distinct cellular States and ecosystems

3D heterotypic models of glioblastoma reveal the impact of microglia on cellular organization and the production of a distinct secretome

Cordyceps sinensis enhances the efficacy of anti-PD-1 immunotherapy in Lewis lung adenocarcinoma

The next layer: augmenting foundation models with structure-preserving and attention-guided learning for local patches to global context awareness in computational pathology

SUMOylation is destined for regulatory T cell-related immune dysregulation

Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC)

Paclitaxel drives TREM2+ macrophage expansion underlying its inferior therapeutic efficacy compared to Nab-paclitaxel

Single-cell transcriptomics identifies fibroblast associated immune heterogeneity and prognostic signatures in bladder cancer

Integrated multi-dataset screening to predict prognosis and identify immunotherapy gene targets in hepatocellular carcinoma patients

Therapeutic potential of targeting MASTL in lung adenocarcinoma

Neoadjuvant modified FOLFIRINOX plus nivolumab in borderline-resectable pancreatic ductal adenocarcinoma: a pilot phase 1 trial

ACACA modulates R-loop homeostasis to enhance lipid metabolism and microenvironmental interactions in ccRCC

Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression

Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Senescence-associated LncRNAs TRMP and TRMP-S promote gastric cancer by activating IGFL4

COL8A1 promotes prostate cancer progression via modulating tumor immune infiltration and activating the FAK/PI3K/AKT pathway through ADAMTS2 regulation

Large-scale single-cell analysis and in silico perturbation reveal dynamic evolution of HCC: from initiation to therapeutic targeting