2026-03-25 3D pentaculture model unveils malignant cell-driven macrophage polarization in high-grade serous ovarian cancer
2026-03-24 Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates
2026-03-23 Use of in vitro co-culture models to inform bacterial engineering for the treatment of solid tumours
2026-03-21 Cancer-associated fibroblasts as key regulators of lipid metabolism in the tumour microenvironment
2026-03-19 A feedback mechanism from prostate cancer cells to macrophages, reinforced by STAT1, regulates tumor progression and resistance to radiotherapy
2026-03-19 Exploring the dual role of extracellular vesicles in coagulation and immune modulation in glioblastoma
2026-03-18 Spatial heterogeneity of MDSCs mediated by ANXA1-FPRs signaling drives immune suppression in OSCC progression
2026-03-17 Computational pathology features of immune architecture predict clinically relevant outcomes in small-cell lung cancer (SCLC)
2026-03-16 Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination
2026-03-13 IL10RB expression in cancer cells is associated with evolutionary changes to solidify treatment resistance
2026-03-10 Integrative spatial profiling pipeline for determining TME architectures in archival clinical specimens using CmTSA superplex technology
2026-03-09 Efficacy and immunomodulatory effect of Claudin18.2-specific IL-7/XCL1 armored CAR-T cells in digestive tract cancer: preclinical and clinical analysis
2026-03-09 Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression
2026-03-06 Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
2026-03-02 The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization
2026-03-02 Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential
2026-03-02 Encoding functional edges in graphs to model spatially varying relationships in the tumor microenvironment
2026-02-26 The research advances of crosstalk between cancer-associated fibroblasts and tumor cells using co-culture organoids
2026-02-26 Navigating the complexities of ferroptosis in pancreatic ductal adenocarcinoma: roles, mechanisms and potential applications
2026-02-26 Visualizing malignant progression: in situ CD109-based spatial immunofluorescence assay delineates papillary to anaplastic thyroid carcinoma transformation within the tumor microenvironment
2026-02-25 Integrative machine learning and molecular docking reveal Narirutin targets ABCC1/ABCG2 for immune microenvironment remodeling in colorectal cancer
2026-02-25 INHBA: a mitochondrial-related pan-cell death gene associated with the prognosis and immunity of OSCC
2026-02-25 DUSP29 does not regulate melanoma–myoblast interactions in a skeletal muscle co-culture model
2026-02-24 Semaphorin 6D drives anti-tumor type I interferon responses to reprogram the tumor microenvironment in colorectal cancer
2026-02-21 Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancer
2026-02-19 CCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness
2026-02-19 Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose–mesenchymal transformation
2026-02-18 Analysis of the mechanism and prognostic value of PRKCQ-AS1 in inhibiting the progression of lung adenocarcinoma via regulating the PD-1/PD-L1 pathway
2026-02-18 Identification of core cytotoxic T lymphocyte-related subtypes, establishment of a prognostic model, and analysis tumor microenvironment infiltration in HNSC
2026-02-18 MOV10, a novel immunotherapy and prognostic biomarker, contributes to glioma development by regulating autophagy
2026-02-17 RBP4 interferes with tongue squamous cell carcinoma progression by inhibiting the PI3K/AKT signaling pathway and promoting macrophage M1-type polarization
2026-02-16 LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial
2026-02-16 Transcriptional activation of LINGO1 facilitates proliferation and immune escape in colorectal cancer
2026-02-15 Chronic inflammation promotes gastric cancer progression via ADAM10-mediated cleavage of CX3CL1
2026-02-15 The MEOX1-PAX1 axis coordinately regulates tumor cell malignancy and Treg differentiation in glioblastoma
2026-02-13 Metabolic crosstalk among cancer-associated fibroblasts, adipocytes and immune cells as an immunosuppressive tumor microenvironment driver
2026-02-13 DCTPP1 drives immunosuppression and poor prognosis in breast cancer by promoting M2 macrophage polarization
2026-02-12 STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways
2026-02-12 Large-Scale Histological Image Dataset with Metadata for Colorectal Cancer Microenvironment
2026-02-12 Integrated bioinformatics and experimental validation identify CCDC78 as a prognostic biomarker in colon adenocarcinoma
2026-02-12 Bacterial colonization of tumors drives immune activation and checkpoint blockade efficacy
2026-02-11 Validation of chemoresistance phenotypes in pleural mesothelioma across 2D, 3D, and in vivo models
2026-02-11 Role of atomic force microscopy in characterization of heterotypic cancer spheroids and their interaction with microplastic particles
2026-02-11 Innate lymphoid cell heterogeneity and etiology-specific reprogramming in hepatocellular carcinoma
2026-02-10 PLOD2 promotes proliferation, migration and invasion of colorectal cancer cells via PI3K-AKT-GSK3β signaling pathway
2026-02-10 Valproic acid reverses macrophage-mediated temozolomide resistance in macrophage-rich gliomas
2026-02-09 Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer
2026-02-09 STING synergizes with TOX suppressing HO-1 expression to trigger ferroptosis in tumor-infiltrating CD8+ T cell and immunotherapy resistance
2026-02-09 Integrative single-cell and machine learning framework reveals prognostic fibroblast subtypes and constructs a fibroblast-related risk signature in lung adenocarcinoma
2026-02-09 DANST enables cell-type deconvolution in spatial transcriptomics using deep domain adversarial neural networks
2026-02-07 Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell’s anti-proliferative effect on cancer cells
2026-02-07 Hepatocytes functionally reprogrammed by KIAA1199-high colorectal cancer cells favour the accumulation of pro-metastatic Egr1+ neutrophils
2026-02-07 Analysis of the transcriptomic and metabolomic landscape of prostate cancer with different anatomical origins using snFLARE-seq and mxFRIZNGRND
2026-02-07 SHH pathway inhibition and astrocyte co-culture induce distinct responses in glioblastoma and cancer stem cells
2026-02-06 Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer
2026-02-06 H19 enhances pancreatic cancer proliferation and invasion by reducing miR-29c-5p’s inhibitory effects on ATF2/ECM1
2026-02-06 Adipocyte-driven STAT3-ANGPT2-PTGIS axis promotes cutaneous metastasis in breast cancer and represents a targetable pathway
2026-02-06 Pembrolizumab and epigenetic modification with azacitidine reshapes the tumor microenvironment of platinum-resistant epithelial ovarian cancer: a phase 2 non-randomized clinical trial
2026-02-06 STAR (stroma-tumor AI risk) assessment: association of AI-derived tumor-stroma proportion with patient survival provides added prognostic value beyond KELIM in epithelial ovarian cancer
2026-02-05 Integrative analyses of metastatic cancer transcriptome reveal clinically distinct cellular States and ecosystems
2026-02-04 3D heterotypic models of glioblastoma reveal the impact of microglia on cellular organization and the production of a distinct secretome
2026-02-04 Cordyceps sinensis enhances the efficacy of anti-PD-1 immunotherapy in Lewis lung adenocarcinoma
2026-02-04 The next layer: augmenting foundation models with structure-preserving and attention-guided learning for local patches to global context awareness in computational pathology
2026-02-03 Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC)
2026-02-03 Paclitaxel drives TREM2+ macrophage expansion underlying its inferior therapeutic efficacy compared to Nab-paclitaxel
2026-02-03 Single-cell transcriptomics identifies fibroblast associated immune heterogeneity and prognostic signatures in bladder cancer
2026-02-03 Integrated multi-dataset screening to predict prognosis and identify immunotherapy gene targets in hepatocellular carcinoma patients
2026-01-31 Neoadjuvant modified FOLFIRINOX plus nivolumab in borderline-resectable pancreatic ductal adenocarcinoma: a pilot phase 1 trial
2026-01-31 ACACA modulates R-loop homeostasis to enhance lipid metabolism and microenvironmental interactions in ccRCC
2026-01-30 Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression
2026-01-30 Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity
2026-01-30 Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma
2026-01-30 COL8A1 promotes prostate cancer progression via modulating tumor immune infiltration and activating the FAK/PI3K/AKT pathway through ADAMTS2 regulation
2026-01-30 Large-scale single-cell analysis and in silico perturbation reveal dynamic evolution of HCC: from initiation to therapeutic targeting
2026-01-30 Decoding the ERS–CAF immunoregulatory axis via multimodal AI and its pan-cancer prognostic and therapeutic predictive value
2026-01-28 Molecular profiling of primary versus paired asynchronous metastatic clear cell renal cell carcinoma reveals heterogeneity in tumor immune microenvironment
2026-01-28 Multimodal single-cell profiling reveals crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients
2026-01-26 A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities
2026-01-26 Priming versus propagating: distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice
2026-01-26 Co-delivery of chemokine CXCL9 and costimulatory ligand TNFSF9 by mesenchymal stem cells reprograms the immune microenvironment for triple-negative breast cancer
2026-01-24 Research on the molecular mechanism of celastrol targeting CTNNB1/STAT3 to inhibit uveal melanoma based on network pharmacology and multi-omics analysis
2026-01-24 Identification and characterization of MARCO-expressing tumor-associated macrophages in pancreatic ductal adenocarcinoma with pan-cancer relevance
2026-01-23 An integrated single-cell lung cancer atlas reveals distinct fibroblast phenotypes between adenocarcinoma and squamous cell carcinomas
2026-01-22 A deep learning radiopathomic signature predicts recurrence risk of hepatocellular carcinoma after hepatectomy
2026-01-21 In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy
2026-01-21 Application of group A streptococcal collagen-like protein 1-expressing Lactococcus as a novel immunotherapeutic against pancreatic ductal adenocarcinoma
2026-01-21 Towards the tumor microenvironment scoring methods for immune checkpoint inhibitor response
2026-01-21 Preoperative positive ctDNA analysis is associated with the tumor microenvironment, and the risk of recurrence in non-metastatic colorectal cancer
2026-01-20 Identification and verification of SPP1 in anoikis as a prognostic biomarker for intestinal metaplasia and gastric cancer
2026-01-20 Evaluation of immuno-oncologic biomarkers and β-catenin expression in response of hepatocellular carcinomas to immunotherapy
2026-01-19 In vitro experiments and bioinformatic analyses implicate KAT2A in the occurrence and development of hepatocellular carcinoma
2026-01-19 Identification of TMEM59L as a potential diagnosis, prognosis and immunotherapy biomarker for colon adenocarcinoma
2026-01-18 The tumor microenvironment in esophageal cancer and its association with clinical features and neoadjuvant treatment response
2026-01-17 Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells
2026-01-17 Neoadjuvant sintilimab, albumin-bound paclitaxel, and carboplatin for locally advanced, resectable esophageal squamous cell carcinoma: clinical study and mechanistic exploration
2026-01-16 Robust and interpretable prediction of gene markers and cell types from spatial transcriptomics data
2026-01-16 Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis
2026-01-16 Spatiotemporally controlled drug release via a click-release system utilizing mono-alkyl-hydroxylamine and cyclooctyne chemistry
2026-01-14 Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression