Eco-friendly RP-HPLC determination of bambuterol hydrochloride and montelukast sodium in tablet dosage with dissolution analysis

Cleaner Tests for Common Asthma Medicines

When we take a tablet for asthma or allergies, few of us think about the chemical tests that guarantee every pill has the right dose and dissolves properly. Those tests are essential for safety—but they can also consume toxic solvents and generate hazardous waste. This study shows how routine quality checks for two widely used asthma medicines can be made much kinder to lab workers and the environment, without sacrificing reliability.

Why These Two Drugs Matter

The work focuses on a combination tablet that contains bambuterol hydrochloride and montelukast sodium. Together, these medicines help keep airways open and reduce inflammation in people with asthma. Manufacturers must confirm that both drugs are present in the correct amount in each batch of tablets, and that the tablets release the drugs quickly and completely once swallowed. That requires sensitive laboratory methods capable of separating and measuring both substances in a complex mixture of tablet ingredients and dissolution fluid.

A Gentler Way to Separate Medicines

The researchers refined a technique called high‑performance liquid chromatography, which separates components of a mixture as they travel through a packed column. Many existing methods for these drugs rely on strong organic solvents such as acetonitrile, methanol, or even more hazardous additives. Instead, this team designed an \

Citation: Ibrahim, M., Ramadan, N.K., Ibrahim, M.M. et al. Eco-friendly RP-HPLC determination of bambuterol hydrochloride and montelukast sodium in tablet dosage with dissolution analysis. Sci Rep 16, 9676 (2026). https://doi.org/10.1038/s41598-026-41125-x

Keywords: green analytical chemistry, HPLC, bambuterol, montelukast, pharmaceutical quality control