2026-03-16 Androgen receptor-dependent DRAM1 activation drives autophagic resistance to BRAF inhibitors in BRAFV600-mutant melanoma
2026-03-16 VS-4718 enhances apoptosis induced by low-dose carfilzomib and overcomes carfilzomib resistance in PSMB5-mutated proteasome inhibitor resistant multiple myeloma
2026-03-11 Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics
2026-02-27 ROR1-PI3K/AKT signaling drives adaptive resistance to cell cycle blockade in TP53 mutated ovarian cancer
2026-02-26 Growth rate-driven modelling suggests that phenotypic adaptation drives drug resistance in BRAFV600E-mutant melanoma
2026-02-25 Integrative machine learning and molecular docking reveal Narirutin targets ABCC1/ABCG2 for immune microenvironment remodeling in colorectal cancer
2026-02-24 Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis
2026-02-23 PDHA1–acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer
2026-02-19 Interplay between autophagy and p38 MAPK during salinomycin-induced cell death in cisplatin-resistant melanoma
2026-02-17 Modulating metabolic signatures to mitigate cabozantinib resistance in FLT3-ITD acute myeloid leukemia cell models
2026-02-16 Metadynamics reveals luteolin-mediated conformational stabilization against avapritinib-resistant PDGFRα D842V/G680R GIST
2026-02-16 First insight of characteristics and prediction of Mycobacterium tuberculosis drug resistance by whole genome sequencing in Fujian Province, China
2026-02-12 JAK/STAT1-interferon-ISGylation networks in breast cancer resistance to inhibitors of FOXM1 and CDK4/6
2026-02-08 A novel human acute myeloid leukemia cell line SDEY-AML1 with KMT2A: MLLT3, IKZF1: EVX1 fusions exhibits high tumorigenicity in NSG mice
2026-02-07 Pan-RAF inhibitor exarafenib targets BRAF class II/III NSCLC and reveals ARAF-KSR1 resistance and combination strategies
2026-02-05 Synergistic targeting of the ARID2–MYC axis by pomalidomide and panobinostat overcomes intrinsic IMiD resistance in multiple myeloma
2026-02-04 Inhibition mechanism of the fungal β−1,3-glucan synthases by triterpenoid antifungal drugs
2026-02-04 3D heterotypic models of glioblastoma reveal the impact of microglia on cellular organization and the production of a distinct secretome
2026-01-31 Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C
2026-01-28 Targeting GNG4 inhibits tumor progression and restores enzalutamide sensitivity in prostate cancer by suppressing autophagy
2026-01-28 Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery
2026-01-27 High prevalence of Trypanosoma spp. and apparent trypanocidal drugs inefficacy in cattle in Al Radom National Park, Sudan
2026-01-27 HIV persistence in tissues on dolutegravir-based therapy is not associated with resistance mutations to dolutegravir
2026-01-26 YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice
2026-01-19 Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer
2026-01-16 Virtual screening of novel alkaloids as potent inhibitors for G2032R-mutant ROS1 kinase in non-small-cell lung cancer
2026-01-14 EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge
2026-01-14 APOBEC3B enhances the efficacy of PARP inhibitors in elimination of ovarian cancer stem cell
2026-01-13 Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis
2026-01-13 Hepatitis B immune escape and drug resistance mutations among blood donors in Gabon during the year 2022
2026-01-10 Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors
2026-01-09 Integrative analysis of proteomics and metabolomics reveals amino acid metabolism disorder in adriamycin-resistant acute myeloid leukemia cells