Clear Sky Science – Articles (en)

CANCER METABOLISM ARTICLES

Suppression of mitochondrial energy production by a photosynthetic bacterial cupredoxin peptide inhibits tumor growth

Serum lipid alterations in oral squamous cell carcinoma and oral potentially malignant disorders: A systematic review and meta-analysis

The fluoroquinoline compound exerts anti-erythroleukemic effects by dual-targeting GLUT1 and the PI3K/AKT signaling pathway

The oncogenic control of nucleotide synthesis

AdipoR1–AMPK axis suppresses breast cancer across molecular subtypes via multimodal cell death pathways, including ferroptosis and apoptosis

Glioblastoma cells that evade chemoradiotherapy-induced cell death exhibit a bifurcated glycolytic program

AATF supports proliferation of glioblastoma cells by sustaining mitochondrial respiration through an NRF-1-dependent mechanism

Metabolic orchestration driven by GGCT: diverting glutamine to glutathione biosynthesis while enhancing glucose anaplerosis for tumor proliferation

Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma

HNF4α-HKDC1 axis orchestrates a metabolic rewiring to promote migration and metastasis in advanced gastric cancer

Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications

Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma

Cereblon (CRBN) inhibits prostate cancer metastasis by negatively regulating 6-phosphogluconate dehydrogenase (6PGD)

Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression

Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation

Absolute dynamic and relative static: the relationship of glycolysis and OXPHOS in cancer development

GPR54 regulates non-small cell lung cancer development via dopa decarboxylase

A Lamp2a-linked RNA secreted by ADSCs prevents ENO1–lactylation–glycolysis feedback and cell malignant behavior in triple-negative breast cancer

The landscape of the intestinal microbiome among patients with newly diagnosed invasive breast cancer and ductal carcinoma in situ (DCIS)

Navigating the complexities of ferroptosis in pancreatic ductal adenocarcinoma: roles, mechanisms and potential applications

The molecular mechanisms and potential therapeutic implications of the crosstalk between DNA methylation and metabolic reprogramming in thyroid cancer

PDHA1–acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer

ITGA8 suppresses proliferation and metastasis of lung adenocarcinoma through the inhibition of glycolysis

Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence

Discovery of hydroxytriazole as a potential glyoxalase-I inhibitor utilizing computer-aided drug design techniques

Taurine is a natural suppressor of urea cycle via targeting ASL

Modulating metabolic signatures to mitigate cabozantinib resistance in FLT3-ITD acute myeloid leukemia cell models

USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression

Metabolic crosstalk among cancer-associated fibroblasts, adipocytes and immune cells as an immunosuppressive tumor microenvironment driver

Structural and molecular basis for allosteric regulation and catalytic coupling of human phosphoribosylformylglycinamidine synthase

PFDN2 stabilizes PYCR2 to activate Wnt/β-catenin signaling and promote colorectal cancer progression

Estrogen receptor β target gene expression reveals novel repressive functions in aggressive breast cancer

Metabolomic and transcriptomic analyses identify metabolic alterations and immune suppression in ovarian cancer

Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC)

CNOT2 /c-Myc/STAT3 signaling is critically involved in glycolysis mediated apoptosis of benzyl isothiocyanate in hepatocellular carcinoma

Targeting glycerophospholipid biosynthesis overcomes chemoresistance driven by SLFN11 loss in Ewing sarcoma

Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells

Spatial gene expression analysis reveals drivers of extremely early lymph node metastasis in breast cancer

Deploying the high-throughput virtual screening (HTVS) approach for the identification of new lactate dehydrogenase (LDH) inhibitors with anticancer assets

Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer

The emerging role of SPHK1 at the immune-metabolic interface: a pan-cancer integrative analysis

Integrated proteomics and metabolomics reveal phytosesquiterpene lactones inhibit TNBC cell activity by depleting ATP synthesis and reprogramming primary metabolism

MAT2A enhances PARN transcription via SRF to accelerate glycolysis and drive malignant progression in osteosarcoma